A histological and micro-CT investigation in to the effect of NGF and EGF on the periodontal, alveolar bone, root and pulpal healing of replanted molars in a rat model - a pilot study
Identifieur interne : 001D46 ( Main/Exploration ); précédent : 001D45; suivant : 001D47A histological and micro-CT investigation in to the effect of NGF and EGF on the periodontal, alveolar bone, root and pulpal healing of replanted molars in a rat model - a pilot study
Auteurs : Francesco Furfaro [Australie] ; Estabelle Sm Ang [Australie] ; Ricky R. Lareu [Australie] ; Kevin Murray [Australie] ; Mithran Goonewardene [Australie]Source :
- Progress in Orthodontics [ 1723-7785 ] ; 2014.
Abstract
This study aims to investigate, utilising micro-computed tomography (micro-CT) and histology, whether the topical application of nerve growth factor (NGF) and/or epidermal growth factor (EGF) can enhance periodontal, alveolar bone, root and pulpal tissue regeneration while minimising the risk of pulpal necrosis, root resorption and ankylosis of replanted molars in a rat model.
Twelve four-week-old male Sprague-Dawley rats were divided into four groups: sham, collagen, EGF and NGF. The maxillary right first molar was elevated and replanted with or without a collagen membrane impregnated with either the growth factors EGF or NGF, or a saline solution. Four weeks after replantation, the animals were sacrificed and the posterior maxilla was assessed using histological and micro-CT analysis. The maxillary left first molar served as the control for the corresponding right first molar.
Micro-CT analysis revealed a tendency for all replanted molars to have reduced root length, root volume, alveolar bone height and inter-radicular alveolar bone volume. It appears that the use of the collagen membrane had a negative effect while no positive effect was noted with the incorporation of EGF or NGF. Histologically, the incorporation of the collagen membrane was found to negatively affect pulpal, root, periodontal and alveolar bone healing with pulpal inflammation and hard tissue formation, extensive root resorption and alveolar bone fragmentation. The incorporation of EGF and NGF did not improve root, periodontal or alveolar bone healing. However, EGF was found to improve pulp vascularisation while NGF-improved pulpal architecture and cell organisation, although not to the level of the control group.
Results indicate a possible benefit on pulpal vascularisation and pulpal cell organisation following the incorporation of EGF and NGF, respectively, into the alveolar socket of replanted molars in the rat model. No potential benefit of EGF and NGF was detected in periodontal or root healing, while the use of a collagen membrane carrier was found to have a negative effect on the healing response.
Url:
DOI: 10.1186/2196-1042-15-2
PubMed: 24393534
PubMed Central: 3896721
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A histological and micro-CT investigation in to the effect of NGF and EGF on the periodontal, alveolar bone, root and pulpal healing of replanted molars in a rat model - a pilot study</title><author><name sortKey="Furfaro, Francesco" sort="Furfaro, Francesco" uniqKey="Furfaro F" first="Francesco" last="Furfaro">Francesco Furfaro</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Orthodontics, The University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Orthodontics, The University of Western Australia, Crawley, Western Australia 6009</wicri:regionArea><wicri:noRegion>Western Australia 6009</wicri:noRegion></affiliation></author><author><name sortKey="Ang, Estabelle Sm" sort="Ang, Estabelle Sm" uniqKey="Ang E" first="Estabelle Sm" last="Ang">Estabelle Sm Ang</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Dentistry, The University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Dentistry, The University of Western Australia, Crawley, Western Australia 6009</wicri:regionArea><wicri:noRegion>Western Australia 6009</wicri:noRegion></affiliation></author><author><name sortKey="Lareu, Ricky R" sort="Lareu, Ricky R" uniqKey="Lareu R" first="Ricky R" last="Lareu">Ricky R. Lareu</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Medicine and Pharmacology, The University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine and Pharmacology, The University of Western Australia, Crawley, Western Australia 6009</wicri:regionArea><wicri:noRegion>Western Australia 6009</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">Department of Pharmacy, Curtin University, Bentley, Western Australia 6102, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Pharmacy, Curtin University, Bentley, Western Australia 6102</wicri:regionArea><wicri:noRegion>Western Australia 6102</wicri:noRegion></affiliation></author><author><name sortKey="Murray, Kevin" sort="Murray, Kevin" uniqKey="Murray K" first="Kevin" last="Murray">Kevin Murray</name><affiliation wicri:level="1"><nlm:aff id="I5">Department of Mathematics and Statistics, The University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Mathematics and Statistics, The University of Western Australia, Crawley, Western Australia 6009</wicri:regionArea><wicri:noRegion>Western Australia 6009</wicri:noRegion></affiliation></author><author><name sortKey="Goonewardene, Mithran" sort="Goonewardene, Mithran" uniqKey="Goonewardene M" first="Mithran" last="Goonewardene">Mithran Goonewardene</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Orthodontics, The University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Orthodontics, The University of Western Australia, Crawley, Western Australia 6009</wicri:regionArea><wicri:noRegion>Western Australia 6009</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24393534</idno><idno type="pmc">3896721</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896721</idno><idno type="RBID">PMC:3896721</idno><idno type="doi">10.1186/2196-1042-15-2</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002221</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002221</idno><idno type="wicri:Area/Pmc/Curation">002221</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002221</idno><idno type="wicri:Area/Pmc/Checkpoint">001660</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001660</idno><idno type="wicri:Area/Ncbi/Merge">004C81</idno><idno type="wicri:Area/Ncbi/Curation">004C81</idno><idno type="wicri:Area/Ncbi/Checkpoint">004C81</idno><idno type="wicri:doubleKey">1723-7785:2014:Furfaro F:a:histological:and</idno><idno type="wicri:Area/Main/Merge">001D53</idno><idno type="wicri:Area/Main/Curation">001D46</idno><idno type="wicri:Area/Main/Exploration">001D46</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A histological and micro-CT investigation in to the effect of NGF and EGF on the periodontal, alveolar bone, root and pulpal healing of replanted molars in a rat model - a pilot study</title><author><name sortKey="Furfaro, Francesco" sort="Furfaro, Francesco" uniqKey="Furfaro F" first="Francesco" last="Furfaro">Francesco Furfaro</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Orthodontics, The University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Orthodontics, The University of Western Australia, Crawley, Western Australia 6009</wicri:regionArea><wicri:noRegion>Western Australia 6009</wicri:noRegion></affiliation></author><author><name sortKey="Ang, Estabelle Sm" sort="Ang, Estabelle Sm" uniqKey="Ang E" first="Estabelle Sm" last="Ang">Estabelle Sm Ang</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Dentistry, The University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Dentistry, The University of Western Australia, Crawley, Western Australia 6009</wicri:regionArea><wicri:noRegion>Western Australia 6009</wicri:noRegion></affiliation></author><author><name sortKey="Lareu, Ricky R" sort="Lareu, Ricky R" uniqKey="Lareu R" first="Ricky R" last="Lareu">Ricky R. Lareu</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Medicine and Pharmacology, The University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine and Pharmacology, The University of Western Australia, Crawley, Western Australia 6009</wicri:regionArea><wicri:noRegion>Western Australia 6009</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">Department of Pharmacy, Curtin University, Bentley, Western Australia 6102, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Pharmacy, Curtin University, Bentley, Western Australia 6102</wicri:regionArea><wicri:noRegion>Western Australia 6102</wicri:noRegion></affiliation></author><author><name sortKey="Murray, Kevin" sort="Murray, Kevin" uniqKey="Murray K" first="Kevin" last="Murray">Kevin Murray</name><affiliation wicri:level="1"><nlm:aff id="I5">Department of Mathematics and Statistics, The University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Mathematics and Statistics, The University of Western Australia, Crawley, Western Australia 6009</wicri:regionArea><wicri:noRegion>Western Australia 6009</wicri:noRegion></affiliation></author><author><name sortKey="Goonewardene, Mithran" sort="Goonewardene, Mithran" uniqKey="Goonewardene M" first="Mithran" last="Goonewardene">Mithran Goonewardene</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Orthodontics, The University of Western Australia, Crawley, Western Australia 6009, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Orthodontics, The University of Western Australia, Crawley, Western Australia 6009</wicri:regionArea><wicri:noRegion>Western Australia 6009</wicri:noRegion></affiliation></author></analytic><series><title level="j">Progress in Orthodontics</title><idno type="ISSN">1723-7785</idno><idno type="eISSN">2196-1042</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>This study aims to investigate, utilising micro-computed tomography (micro-CT) and histology, whether the topical application of nerve growth factor (NGF) and/or epidermal growth factor (EGF) can enhance periodontal, alveolar bone, root and pulpal tissue regeneration while minimising the risk of pulpal necrosis, root resorption and ankylosis of replanted molars in a rat model.</p></sec><sec><title>Methods</title><p>Twelve four-week-old male Sprague-Dawley rats were divided into four groups: sham, collagen, EGF and NGF. The maxillary right first molar was elevated and replanted with or without a collagen membrane impregnated with either the growth factors EGF or NGF, or a saline solution. Four weeks after replantation, the animals were sacrificed and the posterior maxilla was assessed using histological and micro-CT analysis. The maxillary left first molar served as the control for the corresponding right first molar.</p></sec><sec><title>Results</title><p>Micro-CT analysis revealed a tendency for all replanted molars to have reduced root length, root volume, alveolar bone height and inter-radicular alveolar bone volume. It appears that the use of the collagen membrane had a negative effect while no positive effect was noted with the incorporation of EGF or NGF. Histologically, the incorporation of the collagen membrane was found to negatively affect pulpal, root, periodontal and alveolar bone healing with pulpal inflammation and hard tissue formation, extensive root resorption and alveolar bone fragmentation. The incorporation of EGF and NGF did not improve root, periodontal or alveolar bone healing. However, EGF was found to improve pulp vascularisation while NGF-improved pulpal architecture and cell organisation, although not to the level of the control group.</p></sec><sec><title>Conclusions</title><p>Results indicate a possible benefit on pulpal vascularisation and pulpal cell organisation following the incorporation of EGF and NGF, respectively, into the alveolar socket of replanted molars in the rat model. No potential benefit of EGF and NGF was detected in periodontal or root healing, while the use of a collagen membrane carrier was found to have a negative effect on the healing response.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Czochrowska, Em" uniqKey="Czochrowska E">EM Czochrowska</name></author><author><name sortKey="Stenvik, A" uniqKey="Stenvik A">A Stenvik</name></author><author><name sortKey="Bjercke, B" uniqKey="Bjercke B">B Bjercke</name></author><author><name sortKey="Zachrisson, Bu" uniqKey="Zachrisson B">BU Zachrisson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jonsson, T" uniqKey="Jonsson T">T Jonsson</name></author><author><name sortKey="Sigurdsson, Tj" uniqKey="Sigurdsson T">TJ Sigurdsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bauss, O" uniqKey="Bauss O">O Bauss</name></author><author><name sortKey="Engelke, W" 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Kristerson</name></author><author><name sortKey="Andreasen, Fm" uniqKey="Andreasen F">FM Andreasen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaigler, D" uniqKey="Kaigler D">D Kaigler</name></author><author><name sortKey="Cirelli, Ja" uniqKey="Cirelli J">JA Cirelli</name></author><author><name sortKey="Giannobile, Wv" uniqKey="Giannobile W">WV Giannobile</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="King, Gn" uniqKey="King G">GN King</name></author><author><name sortKey="King, N" uniqKey="King N">N King</name></author><author><name sortKey="Hughes, Fj" uniqKey="Hughes F">FJ Hughes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Claus, I" uniqKey="Claus I">I Claus</name></author><author><name sortKey="Laureys, W" uniqKey="Laureys W">W Laureys</name></author><author><name sortKey="Cornelissen, R" uniqKey="Cornelissen R">R Cornelissen</name></author><author><name sortKey="Dermaut, Lr" uniqKey="Dermaut L">LR Dermaut</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skoglund, A" uniqKey="Skoglund A">A Skoglund</name></author><author><name sortKey="Tronstad, L" uniqKey="Tronstad L">L Tronstad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kristerson, L" uniqKey="Kristerson L">L Kristerson</name></author><author><name sortKey="Andreasen, Jo" uniqKey="Andreasen J">JO Andreasen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skoglund, A" uniqKey="Skoglund A">A Skoglund</name></author><author><name sortKey="Tronstad, L" uniqKey="Tronstad L">L Tronstad</name></author><author><name sortKey="Wallenius, K" uniqKey="Wallenius K">K Wallenius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schreiber, Ab" uniqKey="Schreiber A">AB Schreiber</name></author><author><name sortKey="Winkler, Me" uniqKey="Winkler M">ME Winkler</name></author><author><name sortKey="Derynck, R" uniqKey="Derynck R">R Derynck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davideau, Jl" uniqKey="Davideau J">JL Davideau</name></author><author><name sortKey="Sahlberg, C" uniqKey="Sahlberg C">C Sahlberg</name></author><author><name sortKey="Thesleff, I" uniqKey="Thesleff I">I Thesleff</name></author><author><name sortKey="Bendal, A" uniqKey="Bendal A">A Bendal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Derringer, K" uniqKey="Derringer K">K Derringer</name></author><author><name sortKey="Linden, R" uniqKey="Linden R">R Linden</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Furfaro, Francesco" sort="Furfaro, Francesco" uniqKey="Furfaro F" first="Francesco" last="Furfaro">Francesco Furfaro</name></noRegion><name sortKey="Ang, Estabelle Sm" sort="Ang, Estabelle Sm" uniqKey="Ang E" first="Estabelle Sm" last="Ang">Estabelle Sm Ang</name><name sortKey="Goonewardene, Mithran" sort="Goonewardene, Mithran" uniqKey="Goonewardene M" first="Mithran" last="Goonewardene">Mithran Goonewardene</name><name sortKey="Lareu, Ricky R" sort="Lareu, Ricky R" uniqKey="Lareu R" first="Ricky R" last="Lareu">Ricky R. Lareu</name><name sortKey="Lareu, Ricky R" sort="Lareu, Ricky R" uniqKey="Lareu R" first="Ricky R" last="Lareu">Ricky R. Lareu</name><name sortKey="Murray, Kevin" sort="Murray, Kevin" uniqKey="Murray K" first="Kevin" last="Murray">Kevin Murray</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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